Motif ID: TFAP2{A,C}.p2

Z-value: 3.041


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Cchr20_+_546377140.371.8e-01Click!
TFAP2Achr6_-_10523424-0.342.1e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_39964001 2.818 CHADL
chondroadherin-like
chr11_-_60819110 2.565 VWCE
von Willebrand factor C and EGF domains
chr2_+_176695658 2.435 NM_014213
 HOXD9
homeobox D9
chr15_+_39573363 2.348 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr5_+_176170041 2.194 NM_133369
 UNC5A
unc-5 homolog A (C. elegans)
chr19_+_39664706 1.996 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr22_-_45311730 1.826 NM_014246
 CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr11_-_60819273 1.790 NM_152718
 VWCE
von Willebrand factor C and EGF domains
chr2_+_120820140 1.722 NM_002193
 INHBB
inhibin, beta B
chr2_-_47650973 1.708 NM_022055
 KCNK12
potassium channel, subfamily K, member 12
chr2_-_45090025 1.686 NM_016932
 SIX2
SIX homeobox 2
chr2_-_236741352 1.617 NM_001485
 GBX2
gastrulation brain homeobox 2
chr5_+_129268352 1.518 NM_175856
 CHSY3
chondroitin sulfate synthase 3
chr10_-_28074752 1.515 NM_173576
 MKX
mohawk homeobox
chr4_-_85638410 1.514 NM_006168
 NKX6-1
NK6 homeobox 1
chr3_+_71885890 1.488 NM_018971
 GPR27
G protein-coupled receptor 27
chr8_+_104582151 1.388 NM_001100117
 RIMS2
regulating synaptic membrane exocytosis 2
chr16_+_66244314 1.386 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_+_29931880 1.349 NM_207313
 TMEM132E
transmembrane protein 132E
chr17_+_45993338 1.346 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
 CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit















Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 125 entries
enrichment   p-value GO term description
1.47 1.40e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.44 1.52e-02 GO:0060562 epithelial tube morphogenesis
1.44 2.21e-02 GO:0045165 cell fate commitment
1.41 9.23e-03 GO:0035239 tube morphogenesis
1.38 4.01e-03 GO:0002009 morphogenesis of an epithelium
1.38 5.47e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.37 1.09e-03 GO:0001568 blood vessel development
1.36 9.38e-04 GO:0001944 vasculature development
1.33 1.63e-03 GO:0007411 axon guidance
1.32 1.18e-02 GO:0048729 tissue morphogenesis
1.31 3.88e-05 GO:0000904 cell morphogenesis involved in differentiation
1.30 8.88e-05 GO:0031175 neuron projection development
1.30 2.66e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.30 1.05e-03 GO:0007409 axonogenesis
1.29 3.46e-07 GO:0030182 neuron differentiation
1.29 3.17e-06 GO:0032989 cellular component morphogenesis
1.29 1.04e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.29 1.34e-03 GO:0048812 neuron projection morphogenesis
1.28 3.05e-08 GO:0048699 generation of neurons
1.28 6.22e-05 GO:0048666 neuron development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
1.49 6.40e-03 GO:0030055 cell-substrate junction
1.48 1.34e-02 GO:0005924 cell-substrate adherens junction
1.48 1.75e-02 GO:0005925 focal adhesion
1.45 1.16e-03 GO:0005912 adherens junction
1.42 1.30e-02 GO:0031301 integral to organelle membrane
1.36 2.86e-02 GO:0070161 anchoring junction
1.31 3.11e-03 GO:0015629 actin cytoskeleton
1.30 1.17e-04 GO:0043005 neuron projection
1.25 2.38e-03 GO:0000139 Golgi membrane
1.24 3.54e-04 GO:0044431 Golgi apparatus part
1.20 5.07e-09 GO:0012505 endomembrane system
1.19 1.70e-04 GO:0005794 Golgi apparatus
1.17 1.28e-09 GO:0044428 nuclear part
1.16 1.35e-06 GO:0031981 nuclear lumen
1.16 3.72e-02 GO:0042995 cell projection
1.15 3.55e-07 GO:0031090 organelle membrane
1.15 1.79e-03 GO:0005654 nucleoplasm
1.14 7.73e-07 GO:0070013 intracellular organelle lumen
1.14 2.06e-06 GO:0043233 organelle lumen
1.14 2.16e-06 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.33 3.55e-04 GO:0016563 transcription activator activity
1.30 1.01e-04 GO:0019904 protein domain specific binding
1.29 9.75e-08 GO:0043565 sequence-specific DNA binding
1.28 1.79e-02 GO:0016564 transcription repressor activity
1.26 4.56e-10 GO:0030528 transcription regulator activity
1.26 4.68e-02 GO:0003779 actin binding
1.23 3.24e-07 GO:0001071 nucleic acid binding transcription factor activity
1.23 3.24e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.22 7.69e-03 GO:0008092 cytoskeletal protein binding
1.19 1.11e-02 GO:0019899 enzyme binding
1.19 1.27e-02 GO:0042802 identical protein binding
1.13 8.45e-29 GO:0005515 protein binding
1.10 7.76e-03 GO:0003677 DNA binding
1.10 2.74e-02 GO:0000166 nucleotide binding
1.06 6.12e-18 GO:0005488 binding
1.06 3.73e-02 GO:0003824 catalytic activity