Motif ID: TFAP2{A,C}.p2

Z-value: 3.041


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Cchr20_+_546377140.371.8e-01Click!
TFAP2Achr6_-_10523424-0.342.1e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_39964001 2.818 CHADL
chondroadherin-like
chr11_-_60819110 2.565 VWCE
von Willebrand factor C and EGF domains
chr2_+_176695658 2.435 NM_014213
HOXD9
homeobox D9
chr15_+_39573363 2.348 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr5_+_176170041 2.194 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr19_+_39664706 1.996 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr22_-_45311730 1.826 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr11_-_60819273 1.790 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr2_+_120820140 1.722 NM_002193
INHBB
inhibin, beta B
chr2_-_47650973 1.708 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr2_-_45090025 1.686 NM_016932
SIX2
SIX homeobox 2
chr2_-_236741352 1.617 NM_001485
GBX2
gastrulation brain homeobox 2
chr5_+_129268352 1.518 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr10_-_28074752 1.515 NM_173576
MKX
mohawk homeobox
chr4_-_85638410 1.514 NM_006168
NKX6-1
NK6 homeobox 1
chr3_+_71885890 1.488 NM_018971
GPR27
G protein-coupled receptor 27
chr8_+_104582151 1.388 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr16_+_66244314 1.386 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_+_29931880 1.349 NM_207313
TMEM132E
transmembrane protein 132E
chr17_+_45993338 1.346 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr9_+_94987032 1.340 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr11_+_62136788 1.334 NM_000327
ROM1
retinal outer segment membrane protein 1
chr5_+_170668892 1.327 NM_021025
TLX3
T-cell leukemia homeobox 3
chr5_-_94646033 1.327 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr6_+_19945578 1.304 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr19_+_50004134 1.298 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr10_+_122206455 1.290 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr2_+_176702667 1.256 NM_019558
HOXD8
homeobox D8
chr6_+_41714171 1.253 NM_005586
MDFI
MyoD family inhibitor
chr15_+_49421004 1.249 NM_181789
GLDN
gliomedin
chr1_+_33494745 1.227 NM_152493
ZNF362
zinc finger protein 362
chr3_-_130807865 1.187 NM_015103
PLXND1
plexin D1
chr7_-_150495799 1.175 NM_001098834
GBX1
gastrulation brain homeobox 1
chr2_+_176680251 1.167 NM_021192
HOXD11
homeobox D11
chr7_-_123460722 1.162 NM_001136002
TMEM229A
transmembrane protein 229A
chr12_-_1573591 1.161 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr2_+_241586927 1.160 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr21_+_36993860 1.151 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr4_-_123092358 1.150 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr17_-_59131194 1.142 LIMD2
LIM domain containing 2
chr10_+_101079099 1.137 CNNM1
cyclin M1
chr7_+_140420500 1.132 NM_001195278
LOC100131199
transmembrane protein 178-like
chr20_-_55274497 1.125 BMP7
bone morphogenetic protein 7
chr19_+_38804694 1.122 NM_001127895
NM_001127896
CHST8

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

chr10_-_76829857 1.110 ZNF503
zinc finger protein 503
chr16_-_49742651 1.105 NM_002968
SALL1
sal-like 1 (Drosophila)
chr15_-_66511488 1.103 NM_001004439
ITGA11
integrin, alpha 11
chr10_+_42892506 1.094 NM_020630
NM_020975
RET

ret proto-oncogene

chr12_+_2032649 1.093 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr13_+_87122778 1.082 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr7_+_94374862 1.066 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr10_+_80672842 1.061 ZMIZ1
zinc finger, MIZ-type containing 1
chr10_-_131652364 1.055 EBF3
early B-cell factor 3
chr10_-_99780336 1.052 CRTAC1
cartilage acidic protein 1
chr11_-_407324 1.052 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr22_+_29361672 1.046 NM_001001479
SLC35E4
solute carrier family 35, member E4
chr17_+_56831951 1.043 NM_005994
TBX2
T-box 2
chr6_+_5030718 1.042 NM_001145115
PPP1R3G
protein phosphatase 1, regulatory (inhibitor) subunit 3G
chr12_+_109956210 1.040 NM_015267
CUX2
cut-like homeobox 2
chr7_-_35260213 1.038 NM_001077653
NM_001166220
TBX20

T-box 20

chr1_-_6243621 1.037 NM_207370
GPR153
G protein-coupled receptor 153
chr10_+_120779217 1.030 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr5_-_172594691 1.027 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr18_+_18969724 1.026 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr6_+_1336077 1.011


chr3_+_148610516 1.005 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr20_+_60810610 0.998 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr2_-_219633481 0.998 NM_002181
IHH
Indian hedgehog
chr17_+_56832255 0.995 TBX2
T-box 2
chr11_+_7229976 0.991 SYT9
synaptotagmin IX
chr13_+_30378311 0.991 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr3_-_124650081 0.990 NM_183357
ADCY5
adenylate cyclase 5
chr19_-_51081147 0.981 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr2_-_135193011 0.977 NM_030923
TMEM163
transmembrane protein 163
chr22_-_22440054 0.968 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr1_+_2975590 0.967 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr22_-_17891777 0.964 CLDN5
claudin 5
chr18_+_53253775 0.960 NM_004852
ONECUT2
one cut homeobox 2
chr1_-_99242765 0.952 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr10_-_123347493 0.947 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr20_-_43953036 0.942 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr6_-_117193505 0.941 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr10_-_88116181 0.938 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr3_+_50687675 0.936 NM_004947
DOCK3
dedicator of cytokinesis 3
chr2_-_39040981 0.936 LOC375196
hypothetical LOC375196
chr20_-_4177519 0.935 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr10_+_123912930 0.934 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_153560351 0.932 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chr1_-_6468108 0.931 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr11_-_65082208 0.929 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr12_+_93066370 0.928 NM_005761
PLXNC1
plexin C1
chr9_+_134027154 0.923 NM_032536
NTNG2
netrin G2
chr14_+_68796621 0.919 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr12_-_56418295 0.918 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_+_68641802 0.911 NM_015686
FAM155B
family with sequence similarity 155, member B
chr1_-_1157284 0.903 NM_016176
NM_016547
SDF4

stromal cell derived factor 4

chr3_+_182912769 0.903 SOX2
SRY (sex determining region Y)-box 2
chr16_+_19087035 0.898 NM_016524
SYT17
synaptotagmin XVII
chr12_-_120389419 0.896 KDM2B
lysine (K)-specific demethylase 2B
chr1_+_112852892 0.894 NM_024494
WNT2B
wingless-type MMTV integration site family, member 2B
chr11_-_45643711 0.891 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr4_+_19864332 0.887 NM_004787
SLIT2
slit homolog 2 (Drosophila)
chr8_-_144583718 0.884 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr1_+_229365296 0.880 NM_001004342
TRIM67
tripartite motif containing 67
chr6_+_1335067 0.880 NM_001452
FOXF2
forkhead box F2
chr3_-_71886203 0.876 NM_001134649
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr13_-_94162249 0.875 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr11_+_63829616 0.873 NM_004451
ESRRA
estrogen-related receptor alpha
chr3_+_50217692 0.870 NM_006841
SLC38A3
solute carrier family 38, member 3
chr14_+_89597860 0.865 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr11_+_74629597 0.856 NM_001195528
LOC441617
hypothetical LOC441617
chr20_-_21326046 0.855 NM_033176
NKX2-4
NK2 homeobox 4
chr12_+_6363482 0.853 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr20_+_254205 0.852 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr15_+_82113813 0.851 NM_207517
ADAMTSL3
ADAMTS-like 3
chr14_+_69021149 0.848 NM_001161498
UPF0639
UPF0639 protein
chr3_+_129690735 0.846


chr11_-_65082705 0.843 LTBP3
latent transforming growth factor beta binding protein 3
chr17_+_1906262 0.841 NM_001098202
HIC1
hypermethylated in cancer 1
chr1_-_94779727 0.838 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr14_-_100104014 0.828 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr1_-_38285033 0.827 NM_002699
POU3F1
POU class 3 homeobox 1
chr14_-_64416307 0.825 SPTB
spectrin, beta, erythrocytic
chr1_+_226937732 0.824 RHOU
ras homolog gene family, member U
chr2_+_46623396 0.824 RHOQ
ras homolog gene family, member Q
chr17_+_52026058 0.823 NM_005450
NOG
noggin
chr16_+_52877009 0.823


chr1_-_25128951 0.822 RUNX3
runt-related transcription factor 3
chr4_+_185064799 0.821 STOX2
storkhead box 2
chr14_-_59001603 0.820 GPR135
G protein-coupled receptor 135
chr3_-_24511456 0.817 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr21_-_27139143 0.816 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_-_134449467 0.815 NM_177400
NKX6-2
NK6 homeobox 2
chr1_+_22909916 0.815 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr9_-_139316523 0.808 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr17_+_62391216 0.806 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr13_+_95541093 0.804 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr9_+_136673534 0.802 COL5A1
collagen, type V, alpha 1
chr1_+_100777044 0.800 GPR88
G protein-coupled receptor 88
chr20_-_24986501 0.799 ACSS1
acyl-CoA synthetase short-chain family member 1
chr11_+_7229717 0.797 NM_175733
SYT9
synaptotagmin IX
chr19_-_51168396 0.796 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr16_+_65591916 0.794 NM_001190201
NM_001190202
CES4A

carboxylesterase 4A

chr8_-_97242119 0.794 NM_001001557
GDF6
growth differentiation factor 6
chr18_-_22383066 0.792 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chrX_-_53367246 0.789 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr17_+_72376022 0.789 NM_144677
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr22_-_49315341 0.788 NM_001113755
NM_001953
TYMP

thymidine phosphorylase

chr22_-_30071565 0.783 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr10_+_50488352 0.780 NM_003055
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3
chr7_-_27206249 0.775 NM_000522
HOXA13
homeobox A13
chr2_-_236740710 0.774


chr15_-_38362078 0.773 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr19_+_45389356 0.772 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr18_-_53621277 0.768 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr16_-_76026431 0.763 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr11_+_93917214 0.761 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr8_-_53640520 0.760 NM_207413
FAM150A
family with sequence similarity 150, member A
chr20_+_30019465 0.760 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr17_-_6400470 0.759 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr10_-_118491971 0.758 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr20_+_56659693 0.757 NM_001001433
NM_001134772
NM_001134773
NM_003763
STX16



syntaxin 16



chr15_+_97462675 0.755 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr9_+_128128913 0.753 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr13_+_77170470 0.751 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr1_-_202387767 0.751 NM_018208
ETNK2
ethanolamine kinase 2
chr21_+_36993302 0.750


chr3_+_50167851 0.749 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr2_+_26924466 0.748 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr14_-_76677711 0.746 ZDHHC22
zinc finger, DHHC-type containing 22
chr22_+_48740432 0.744 PIM3
pim-3 oncogene
chr5_+_140326473 0.744 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr20_+_41976831 0.743 NM_001098797
TOX2
TOX high mobility group box family member 2
chr17_+_40655060 0.738 NM_005892
FMNL1
formin-like 1
chr3_+_161425946 0.737 NM_001168214
LOC401097
hypothetical protein LOC401097
chr7_-_103417198 0.737 NM_005045
NM_173054
RELN

reelin

chr16_-_626293 0.736 NM_001040160
NM_001040161
NM_001040162
NM_001040165
NM_032366
C16orf13




chromosome 16 open reading frame 13




chr22_+_30072739 0.734 FLJ20464
hypothetical protein FLJ20464
chr9_+_128416542 0.734 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr18_-_22382497 0.734 NM_001142730
KCTD1
potassium channel tetramerisation domain containing 1
chr14_-_102045849 0.733 NM_152326
ANKRD9
ankyrin repeat domain 9
chr10_+_123913094 0.732 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr2_+_26768894 0.732 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr1_-_11674264 0.732 NM_001127325
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr7_+_154943466 0.728 NM_001427
EN2
engrailed homeobox 2
chr2_+_171280944 0.726 SP5
Sp5 transcription factor
chr14_-_94306104 0.721 NM_173849
GSC
goosecoid homeobox
chr9_-_119217147 0.718 ASTN2
astrotactin 2
chr7_-_100325209 0.717 NM_001015072
UFSP1
UFM1-specific peptidase 1 (non-functional)
chr10_-_88271466 0.716 WAPAL
wings apart-like homolog (Drosophila)
chr1_-_152741148 0.713 NM_001010846
SHE
Src homology 2 domain containing E
chr22_-_32646325 0.711 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr17_-_45582872 0.711 NM_032595
PPP1R9B
protein phosphatase 1, regulatory (inhibitor) subunit 9B
chr4_-_5945596 0.710 NM_001014809
CRMP1
collapsin response mediator protein 1
chr1_-_50661716 0.709 NM_032110
DMRTA2
DMRT-like family A2
chr7_-_131911808 0.708 NM_001105543
NM_020911
PLXNA4

plexin A4

chr15_+_64782468 0.706 SMAD6
SMAD family member 6
chr6_+_137285071 0.705 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr16_-_11257539 0.705 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr9_-_138150200 0.704 C9orf69
chromosome 9 open reading frame 69

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 5.22e-23 GO:0009987 cellular process
1.10 6.23e-17 GO:0065007 biological regulation
1.10 5.85e-16 GO:0050789 regulation of biological process
1.10 3.71e-15 GO:0050794 regulation of cellular process
1.14 4.03e-14 GO:0044260 cellular macromolecule metabolic process
1.11 2.04e-13 GO:0044237 cellular metabolic process
1.09 6.03e-12 GO:0008152 metabolic process
1.12 2.83e-11 GO:0043170 macromolecule metabolic process
1.10 1.20e-10 GO:0044238 primary metabolic process
1.17 7.25e-10 GO:0048522 positive regulation of cellular process
1.16 2.21e-09 GO:0071842 cellular component organization at cellular level
1.16 2.57e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 1.75e-08 GO:0048518 positive regulation of biological process
1.28 3.05e-08 GO:0048699 generation of neurons
1.13 4.95e-08 GO:0016043 cellular component organization
1.12 5.19e-08 GO:0019222 regulation of metabolic process
1.27 5.43e-08 GO:0022008 neurogenesis
1.13 8.14e-08 GO:0071840 cellular component organization or biogenesis
1.20 8.69e-08 GO:0007399 nervous system development
1.12 1.28e-07 GO:0031323 regulation of cellular metabolic process
1.20 1.36e-07 GO:0009653 anatomical structure morphogenesis
1.29 3.46e-07 GO:0030182 neuron differentiation
1.18 9.86e-07 GO:0023051 regulation of signaling
1.16 1.00e-06 GO:0048523 negative regulation of cellular process
1.25 1.13e-06 GO:0048468 cell development
1.12 1.28e-06 GO:0080090 regulation of primary metabolic process
1.15 2.80e-06 GO:0048519 negative regulation of biological process
1.29 3.17e-06 GO:0032989 cellular component morphogenesis
1.12 3.56e-06 GO:0060255 regulation of macromolecule metabolic process
1.13 9.77e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 1.22e-05 GO:0009966 regulation of signal transduction
1.11 3.58e-05 GO:0006807 nitrogen compound metabolic process
1.31 3.88e-05 GO:0000904 cell morphogenesis involved in differentiation
1.26 4.25e-05 GO:0009790 embryo development
1.22 4.69e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.10 5.39e-05 GO:0032502 developmental process
1.15 5.98e-05 GO:0006464 protein modification process
1.28 6.22e-05 GO:0048666 neuron development
1.16 6.35e-05 GO:0006996 organelle organization
1.11 6.91e-05 GO:0051179 localization
1.27 7.59e-05 GO:0000902 cell morphogenesis
1.14 8.76e-05 GO:0090304 nucleic acid metabolic process
1.30 8.88e-05 GO:0031175 neuron projection development
1.15 9.10e-05 GO:0043412 macromolecule modification
1.26 1.08e-04 GO:0030030 cell projection organization
1.11 1.13e-04 GO:0034641 cellular nitrogen compound metabolic process
1.12 1.21e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.12 1.73e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.14 2.29e-04 GO:0048869 cellular developmental process
1.15 2.44e-04 GO:0048583 regulation of response to stimulus
1.30 2.66e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.14 2.96e-04 GO:0030154 cell differentiation
1.10 3.00e-04 GO:0007275 multicellular organismal development
1.12 3.04e-04 GO:0044267 cellular protein metabolic process
1.11 3.07e-04 GO:0048731 system development
1.21 4.51e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.10 4.76e-04 GO:0023052 signaling
1.12 5.13e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 6.66e-04 GO:0009892 negative regulation of metabolic process
1.19 7.14e-04 GO:0043067 regulation of programmed cell death
1.21 8.58e-04 GO:0016265 death
1.36 9.38e-04 GO:0001944 vasculature development
1.28 9.91e-04 GO:0072358 cardiovascular system development
1.28 9.91e-04 GO:0072359 circulatory system development
1.29 1.04e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.30 1.05e-03 GO:0007409 axonogenesis
1.19 1.06e-03 GO:0010941 regulation of cell death
1.37 1.09e-03 GO:0001568 blood vessel development
1.17 1.11e-03 GO:0009893 positive regulation of metabolic process
1.18 1.22e-03 GO:0031325 positive regulation of cellular metabolic process
1.12 1.24e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 1.30e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.29 1.34e-03 GO:0048812 neuron projection morphogenesis
1.10 1.50e-03 GO:0048856 anatomical structure development
1.18 1.51e-03 GO:0010646 regulation of cell communication
1.27 1.51e-03 GO:0032990 cell part morphogenesis
1.27 1.53e-03 GO:0048858 cell projection morphogenesis
1.20 1.54e-03 GO:0031324 negative regulation of cellular metabolic process
1.33 1.63e-03 GO:0007411 axon guidance
1.20 1.90e-03 GO:0008219 cell death
1.17 1.92e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.18 2.20e-03 GO:0042981 regulation of apoptosis
1.11 2.27e-03 GO:0009889 regulation of biosynthetic process
1.18 2.33e-03 GO:0007049 cell cycle
1.23 2.47e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.24 2.91e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.10 3.03e-03 GO:0019538 protein metabolic process
1.23 3.26e-03 GO:0010628 positive regulation of gene expression
1.11 3.31e-03 GO:0031326 regulation of cellular biosynthetic process
1.26 3.86e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.38 4.01e-03 GO:0002009 morphogenesis of an epithelium
1.11 4.04e-03 GO:0010468 regulation of gene expression
1.22 4.40e-03 GO:0009890 negative regulation of biosynthetic process
1.09 4.58e-03 GO:0007165 signal transduction
1.38 5.47e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.15 5.73e-03 GO:0035556 intracellular signal transduction
1.08 6.87e-03 GO:0051716 cellular response to stimulus
1.12 6.98e-03 GO:0006355 regulation of transcription, DNA-dependent
1.10 7.15e-03 GO:0051234 establishment of localization
1.15 7.44e-03 GO:0065009 regulation of molecular function
1.11 8.49e-03 GO:0051252 regulation of RNA metabolic process
1.24 8.96e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.41 9.23e-03 GO:0035239 tube morphogenesis
1.20 1.11e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.32 1.18e-02 GO:0048729 tissue morphogenesis
1.22 1.27e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.21 1.32e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.47 1.40e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.44 1.52e-02 GO:0060562 epithelial tube morphogenesis
1.18 1.59e-02 GO:0006351 transcription, DNA-dependent
1.20 1.59e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 1.78e-02 GO:0010629 negative regulation of gene expression
1.23 2.03e-02 GO:0051253 negative regulation of RNA metabolic process
1.09 2.13e-02 GO:0006810 transport
1.44 2.21e-02 GO:0045165 cell fate commitment
1.21 2.34e-02 GO:0045595 regulation of cell differentiation
1.20 2.40e-02 GO:0012501 programmed cell death
1.15 2.43e-02 GO:0051641 cellular localization
1.18 3.28e-02 GO:0050793 regulation of developmental process
1.19 3.51e-02 GO:0031399 regulation of protein modification process
1.21 3.61e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.16 4.09e-02 GO:0032268 regulation of cellular protein metabolic process
1.22 4.44e-02 GO:0000278 mitotic cell cycle
1.21 4.63e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.12 4.96e-02 GO:0034645 cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 2.96e-26 GO:0044424 intracellular part
1.07 3.21e-25 GO:0005622 intracellular
1.09 3.94e-20 GO:0043227 membrane-bounded organelle
1.09 7.17e-20 GO:0005737 cytoplasm
1.09 1.36e-19 GO:0043231 intracellular membrane-bounded organelle
1.08 2.75e-19 GO:0043226 organelle
1.08 6.94e-19 GO:0043229 intracellular organelle
1.11 4.13e-13 GO:0044446 intracellular organelle part
1.11 5.04e-13 GO:0044422 organelle part
1.10 9.56e-12 GO:0044444 cytoplasmic part
1.10 1.49e-11 GO:0005634 nucleus
1.17 1.28e-09 GO:0044428 nuclear part
1.20 5.07e-09 GO:0012505 endomembrane system
1.15 3.55e-07 GO:0031090 organelle membrane
1.14 7.73e-07 GO:0070013 intracellular organelle lumen
1.16 1.35e-06 GO:0031981 nuclear lumen
1.14 2.06e-06 GO:0043233 organelle lumen
1.14 2.16e-06 GO:0031974 membrane-enclosed lumen
1.14 2.15e-05 GO:0005829 cytosol
1.30 1.17e-04 GO:0043005 neuron projection
1.19 1.70e-04 GO:0005794 Golgi apparatus
1.02 2.36e-04 GO:0005623 cell
1.02 2.71e-04 GO:0044464 cell part
1.24 3.54e-04 GO:0044431 Golgi apparatus part
1.45 1.16e-03 GO:0005912 adherens junction
1.15 1.79e-03 GO:0005654 nucleoplasm
1.25 2.38e-03 GO:0000139 Golgi membrane
1.09 2.85e-03 GO:0043234 protein complex
1.31 3.11e-03 GO:0015629 actin cytoskeleton
1.49 6.40e-03 GO:0030055 cell-substrate junction
1.42 1.30e-02 GO:0031301 integral to organelle membrane
1.48 1.34e-02 GO:0005924 cell-substrate adherens junction
1.48 1.75e-02 GO:0005925 focal adhesion
1.14 1.93e-02 GO:0005783 endoplasmic reticulum
1.36 2.86e-02 GO:0070161 anchoring junction
1.09 3.62e-02 GO:0043228 non-membrane-bounded organelle
1.09 3.62e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.16 3.72e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 8.45e-29 GO:0005515 protein binding
1.06 6.12e-18 GO:0005488 binding
1.26 4.56e-10 GO:0030528 transcription regulator activity
1.29 9.75e-08 GO:0043565 sequence-specific DNA binding
1.23 3.24e-07 GO:0001071 nucleic acid binding transcription factor activity
1.23 3.24e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.30 1.01e-04 GO:0019904 protein domain specific binding
1.33 3.55e-04 GO:0016563 transcription activator activity
1.22 7.69e-03 GO:0008092 cytoskeletal protein binding
1.10 7.76e-03 GO:0003677 DNA binding
1.19 1.11e-02 GO:0019899 enzyme binding
1.19 1.27e-02 GO:0042802 identical protein binding
1.28 1.79e-02 GO:0016564 transcription repressor activity
1.10 2.74e-02 GO:0000166 nucleotide binding
1.06 3.73e-02 GO:0003824 catalytic activity
1.26 4.68e-02 GO:0003779 actin binding